diff --git a/tcmalloc/internal/system_allocator.h b/tcmalloc/internal/system_allocator.h
index fd344b2cd..7d92a94ee 100644
--- a/tcmalloc/internal/system_allocator.h
+++ b/tcmalloc/internal/system_allocator.h
@@ -582,6 +582,17 @@ void* SystemAllocator<Topology, NormalPartitions>::MmapAlignedLocked(
     size_t size, size_t alignment, const MemoryTag tag) {
   using system_allocator_internal::MapFixedNoReplaceFlagAvailable;
 
+  constexpr uintptr_t kTagFree = uintptr_t{1} << kTagShift;
+  // Each memory tag partition spans kTagFree bytes (whereas kTagMask is the
+  // multi-bit mask across all tags), so requests with size or alignment larger
+  // than kTagFree would cross tag boundaries or clear tag bits in
+  // RandomMmapHint.
+  // TODO(b/141325493): Support allocations and alignments larger than kTagFree.
+  if (size == 0 || size > kTagFree || alignment == 0 || alignment > kTagFree ||
+      !absl::has_single_bit(alignment)) {
+    return nullptr;
+  }
+
   TC_ASSERT_LE(size, kTagMask);
   TC_ASSERT_LE(alignment, kTagMask);
 
diff --git a/tcmalloc/internal/system_allocator_test.cc b/tcmalloc/internal/system_allocator_test.cc
index 7c92d091f..e65056a0f 100644
--- a/tcmalloc/internal/system_allocator_test.cc
+++ b/tcmalloc/internal/system_allocator_test.cc
@@ -182,6 +182,22 @@ TEST(SystemAllocatorTest, SetAnonVmaNameHandlesEmptyAndSubstringViews) {
   }
 }
 
+TEST(SystemAllocatorTest, MmapAlignedRejectsOutOfPartitionSizeAndAlignment) {
+  constexpr size_t kMinMmapAlloc = 1 << 30;
+  NumaTopology<2> topology;
+  topology.Init();
+  SystemAllocator<NumaTopology<2>, 1> allocator(topology, kMinMmapAlloc);
+
+  const size_t kPageSize = GetPageSize();
+  constexpr size_t kPartitionSize = uintptr_t{1} << kTagShift;
+  EXPECT_EQ(allocator.MmapAligned(kPageSize, 2 * kPartitionSize,
+                                  MemoryTag::kSampledOrCold),
+            nullptr);
+  EXPECT_EQ(allocator.MmapAligned(kPartitionSize + kPageSize, kPageSize,
+                                  MemoryTag::kNormal),
+            nullptr);
+}
+
 }  // namespace
 }  // namespace tcmalloc_internal
 }  // namespace tcmalloc